Acknowledgment
Acknowledgment of core facility services and instruments supported by Montana State
University are required in publications and are a key performance indicator of a facility's
research activity. Citing core facilities in your publications will help ensure that
core facilities continue to be here to provide training, instrumentation, and support
in the future.
When citing a core facility, please ensure that you are referencing their Research
Resource Identifier (RRID) number, and funding source. A citation example for the
ARC is provided below:
"This work used the Animal Resources Center (RRID:SCR_026351) which is supported by
the Office of Research and Economic Development at Montana State University."
2025 Publications
North RJ, Cooper G, Mears L, Bothner B, Dlakić M, Merzdorf CS. Persistent and Dose-Dependent
Neural and Metabolic Gene Expression Changes Induced by Transient Citalopram Exposure
in Zebrafish Embryos. International Journal of Molecular Sciences. 2025; 26(23):11288. https://doi.org/10.3390/ijms262311288
*Abbott MJ, Norsten CR, Anzick SL, Martens C, Winkler CW, Evans AB (2025 Sep 16).
Orthobunyavirus neurovirulence is a complex trait involving all three genome segments.
bioRxiv : the preprint server for biology, (), . . ID: 41001005.
Pincus SH, Luo K, Peters T, Gordy JT, Cole FM, Klug G, Ober K, Marcotte TK, Markham
RB. J3ExoA: A Novel Anti-HIV Immunotoxin Fusion of Anti-Gp120 J3VHH and PE38 Fragment
of Pseudomonas Exotoxin A. Pharmaceuticals. 2025; 18(9):1305. https://doi.org/10.3390/ph18091305
Snow, M., Cameron, B., Pond, R. et al. An Elongator mouse model of ALS spotlights TDP-43 in the motor neuron nucleolus. Commun Biol 8, 1259 (2025). https://doi.org/10.1038/s42003-025-08701-9
Brown K, Vahidi G, Hislop BD, Moody M, Watson S, Welhaven HD, Behzad R, Paton KO,
Karim L, June RK, Martin SA, Heveran CM (2025 Jun 3). Short-term high-fat diet impacts
bone material properties and metabolism for adult and aged C57BL/6JN mice. Communications
biology, 8(1), 850. . ID: 40461602.
Luu AM, Hatton AA, Gattiker J, Shepardson KM, Hall MN, Benson E, Bimczok D, Rynda-Apple
A (2025 May 28). TLR2 or TLR4 stimulation induces transmembrane (tm)TNF-driven priming
in macrophages which results in improved clearance of a subsequent Staphylococcus
aureus infection. Journal of innate immunity, (), 1-28. doi: 10.1159/000546011. ID:
40435995.
North RJ, Cooper G, Mears L, Bothner B, Dlakić M, Merzdorf CS (2025 May 19). Persistent Transcriptome Alterations in Zebrafish
Embryos After Discontinued Opioid Exposure. Int J Mol Sci. 26(10):4840. doi: https://doi.org/10.3390/ijms26104840
Miettinen HM, Abbott MJ, Evans AB (2025). A mix-and-match reverse genetics system
for evaluating genetic determinants of orthobunyavirus neurological disease. PloS
one, 20(4), e0315694. . ID: 40294121.
Wolfe TM, Jo J, Pinkham NV, Garey KW, Walk ST (Feb 2025).The impact of ibezapolstat
and other Clostridioides difficile infection-relevant antibiotics on the microbiome
of humanized mice. Antimicrob Agents Chemother69:e01604-24.https://doi.org/10.1128/aac.01604-24
*Welhaven HD, Welfley AH, Brahmachary PP, Smith DF, Bothner B, June RK (2025 Feb 7).
Tissue-specific and spatially dependent metabolic signatures perturbed by injury in
skeletally mature male and female mice. bioRxiv : the preprint server for biology,
(), . . ID: 39975211.
Falvo CA, Crowley DE, Benson E, Hall MN, Schwarz B, Bohrnsen E, Ruiz-Aravena M, Hebner
M, Ma W, Schountz T, Rynda-Apple A, Plowright RK (2025 Feb). Diet-induced changes
in metabolism influence immune response and viral shedding in Jamaican fruit bats.
Proceedings. Biological sciences, 292(2041), 20242482. . ID: 39968620.
Cooper G, North R, Hunt-Smith T, Larson J, Rennie M, Bailey ML, Scarlata S, Merzdorf
CS, Bothner B (2025 Jan 26). Persistent Metabolic Changes Are Induced by 24 h Low-Dose
Lead (Pb) Exposure in Zebrafish Embryos. International journal of molecular sciences,
26(3), . . ID: 39940818.
Dauenhauer LA, Hislop BD, Brahmachary P, Devine C, Gibbs D, June RK, Heveran CM (2024
Nov). Aging alters the subchondral bone response 7 days after noninvasive traumatic
joint injury in C57BL/6JN mice. Journal of orthopaedic research : official publication
of the Orthopaedic Research Society, 42(11), 2450-2460. doi: 10.1002/jor.25921. ID:
38923623.
Pincus SH, Cole FM, Ober K, Tokmina-Lukaszewska M, Marcotte T, Kovacs EW, Zhu T, Khasanov
A, Copié V, Peters T (2024 Oct 22). Conjugation of anti-HIV gp41 monoclonal antibody
to a drug capable of targeting resting lymphocytes produces an effective cytotoxic
anti-HIV immunoconjugate. Journal of virology, 98(10), e0064724. . ID: 39283123.
Rynda-Apple A, Reyes Servin J, Lenz J, Roemer J, Benson EE, Hall MN, Shepardson KM
(2024 Oct 15). IFN Receptor 2 Regulates TNF-α-Mediated Damaging Inflammation during
Aspergillus Pulmonary Infection. Journal of immunology (Baltimore, Md. : 1950), 213(8),
1202-1211. . ID: 39212415.
Luu AM, Shepardson KM, Rynda-Apple A (2024 Oct). A Comprehensive Protocol for the
Collection, Differentiation, Cryopreservation, and Resuscitation of Primary Murine
Bone Marrow Derived Macrophages (BMDM). Immunological investigations, 53(7), 1001-1012.
. ID: 39115808.
Chaverra M, Cheney AM, Scheel A, Miller A, George L, Schultz A, Henningsen K, Kominsky
D, Walk H, Kenndey WR, Kaufmann H, Walk S, Copié V, Lefcort F. ELP1, the Gene Mutated in Familial Dysautonomia, Is Required for Normal
Enteric Nervous System Development and Maintenance and for Gut Epithelium Homeostasis.
Journal of Neuroscience 11 September 2024, 44 (37); DOI10.1523/JNEUROSCI.2253-23.2024
Blackwell KH, Walk HMG, Peters LR, Gunlikson EM, Bright JC, Kominsky DJ, Walk ST (2024
Sep 20). A simplified protocol for deriving sterile, infectious murine Heligmosomoides
polygyrus bakeri larvae. STAR protocols, 5(3), 103144. . ID: 39167493.
Vahidi G, Boone C, Hoffman F, Heveran C (2024 Sep). Aging decreases osteocyte peri-lacunar-canalicular
system turnover in female C57BL/6JN mice. Bone, 186(), 117163. . ID: 38857854.
Crowley DE, Falvo CA, Benson E, Hedges J, Jutila M, Ezzatpour S, Aguilar HC, Ruiz-Aravena
M, Ma W, Schountz T, Rynda-Apple A, Plowright RK (2024 Sep). Bats generate lower affinity
but higher diversity antibody responses than those of mice, but pathogen-binding capacity
increases if protein is restricted in their diet. PLoS biology, 22(9), e3002800. .
ID: 39316608.
Costello SM, Schultz A, Smith D, Horan D, Chaverra M, Tripet B, George L, Bothner
B, Lefcort F, Copié V (2024 Jul 31). Metabolic Deficits in the Retina of a Familial
Dysautonomia Mouse Model. Metabolites, 14(8), . . ID: 39195519.
Domanico LF, Dunn GP, Kobiler O, Taylor MP (2024 May 14). A dual fluorescent herpes
simplex virus type 1 recombinant reveals divergent outcomes of neuronal infection.
Journal of virology, 98(5), e0003224. . ID: 38651900.
Fredrikson JP, Domanico LF, Pratt SL, Loveday EK, Taylor MP, Chang CB (2024 Mar).
Single-cell herpes simplex virus type 1 infection of neurons using drop-based microfluidics
reveals heterogeneous replication kinetics. Science advances, 10(9), eadk9185. . ID:
38416818.
Devine CC, Brown KC, Paton KO, Heveran CM, Martin SA (2024 Feb). Rapamycin does not
alter bone microarchitecture or material properties quality in young-adult and aged
female C57BL/6 mice. JBMR plus, 8(2), ziae001. . ID: 38505525.
Hislop BD, Devine C, June RK, Heveran CM. Subchondral bone structure and synovial
fluid metabolism are altered in injured and contralateral limbs 7 days after non-invasive
joint injury in skeletally-mature C57BL/6 mice. Osteoarthritis and Cartilage. 2022,
Vol 30, Issue 12, Pgs 1593-1605. https://doi.org/10.1016/j.joca.2022.09.002
Pincus SH, Kyro A, Maresh GA, Peters T, Kempa J, Marcotte TK, Gao Z, Ye J, Copié V,
Song K. Parenteral Exposure of Mice to Ricin Toxin Induces Fatal Hypoglycemia by Cytokine-Mediated
Suppression of Hepatic Glucose-6-Phosphatase Expression. Toxins. 2022; 14(12):820.
https://doi.org/10.3390/toxins14120820
Wu, HF., Yu, W., Saito-Diaz, K. et al. Norepinephrine transporter defects lead to
sympathetic hyperactivity in Familial Dysautonomia models. Nat Commun 13, 7032 (2022).
https://doi.org/10.1038/s41467-022-34811-7
Kempa J, O’Shea-Stone G, Moss CE, Peters T, Marcotte TK, Tripet B, Eilers B, Bothner
B, Copié V, Pincus SH. Distinct Metabolic States Are Observed in Hypoglycemia Induced
in Mice by Ricin Toxin or by Fasting. Toxins. 2022; 14(12):815. https://doi.org/10.3390/toxins14120815
Walters J, Walters C, Cameron B, George L. Elongator regulates the melanocortin satiety
pathway. Biochemical and Biophysical Research Communications. Vol 613, 2022, Pgs 73-80.https://doi.org/10.1016/j.bbrc.2022.04.128
Hedges JF, Snyder DT, Robison A, Grifka-Walk HM, Blackwell K, Shepardson K, Kominsky
D, Rynda-Apple A, Walcheck B, Jutila MA. An ADAM17-Neutralizing Antibody Reduces Inflammation
and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model. Front. Immunol,
2022, Vol 13. https://doi.org/10.3389/fimmu.2022.918881
Tolman Z, Chaverra M, George L, Lefcort F. Elp1 is required for development of visceral
sensory peripheral and central circuitry. Dis Model Mech. 2022, 15 (5): dmm049274. https://doi.org/10.1242/dmm.049274
Hope D. Welhaven, Ghazal Vahidi, Seth T. Walk, Brian Bothner, Stephen A. Martin, Chelsea
M. Heveran, Ronald K. June, The Cortical Bone Metabolome of C57BL/6J Mice Is Sexually
Dimorphic, JBMR Plus, Volume 6, Issue 7, 1 July 2022, e10654, https://doi.org/10.1002/jbm4.10654
Wallace CW, Hislop B, Hahn AK, Erdogan AE, Brahmachary PP, June RK. Correlations between
metabolites in the synovial fluid and serum: A mouse injury study. Journal of Orthopaedic Research,
Vol 40, Issue 12, Pgs 2792-2802, https://doi.org/10.1002/jor.25310
Rux CJ, Vahidi G, Darabi A, Cox LM, Heveran CM. Perilacunar bone tissue exhibits sub-micrometer
modulus gradation which depends on the recency of osteocyte bone formation in both
young adult and early-old-age female C57Bl/6 mice. Bone. 2022;157:116327. doi:10.1016/j.bone.2022.116327
Minor D, Cavon J, Johnson T, Ontiveros S, Gao D, Quinn MT, Lei B. Host-to-Host Group
A Streptococcus Transmission Causes Infection of the Lamina Propria but Not Epithelium
of the Upper Respiratory Tract in MyD88-Deficient Mice. Infect. Immun. 2022, 90(1):e00423-21.
doi: 10.1128/IAI.00423-21